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Cushing'S Syndrome Caused By Adrenal Tumor


 Cushing syndrome is an endocrine system disorder, occurs when there is a tumor.

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Constant high level of cortical; steroid hormone is main cause of this disease.15% of Cushing syndrome is caused by tumor on one of the gland. Cortisol is released in larger amount by adrenal tumor.

Adrenal tumors are divided into

1)      Cancerous (malignant)

2)      Non-cancerous (benign)

Adrenal tumors are rare and can occur at any age of time. This condition is more common in women than men.

80% of Cushing syndrome is ACTH Dependent  

  • Lung cancers (5%)
  • Pituitary tumors (60%)

ACTH Independent is 20%

  • Malignant adrenal tumors (adrenal cell carcinoma) (10%)
  • Benign adrenal tumors (adenoma) (25%)

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Signs & Symptoms
  • Upper body obesity spl in waist region with thin legs and arms.
  • Moon face (round, red )
  • Slow growth in children
  • Common skin changes include
    - skin infection
    -striae ; purple color marks on abdomen, breast and thigh region
    -increase in skin sensitivity as skin becomes thin and gets bruised easily
  • Common muscle and bone changes includes:
    - muscular weakness
    - thinning of bones
    - buffalo hump ;collection of fat between shoulders
    -bony pain and tenderness
  • Excess growth of hairs on face, neck,chest,abdomen and chest spl in women
  • Menstrual cycle become irregular or stops
  • Decrease in fertility , loss of libido are few of the symptom in men

Other symptom may include:

  • Fatigue
  • Mental change; depression, anxiety,behaviorial changes
  • Headache
  • Back pain
  • Increase thirst and urine output
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Appropriate treatment may help to reduce complications

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Surgery Modern Medicine

Treatment depends on the cause. Surgery is common treatment for removal of tumor followed by radiation therapy.

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